Methylene Blue Dosage

If you are taking prescription medication, please check any interactions here and consult your medical provider before taking Methylene Blue.

Less is more. Too much will disrupt your Gut Microbiome and will have adverse effects on your health.

Start off the morning with 5 drops a day for one week. Then gradually work up to 10 drops a day, taken in the morning. 

Smaller Doses:

  • Beneficial Effects: At lower concentrations, methylene blue has minimal impact on the gut microbiome. For instance, a daily dose calculated based on 1 to 8 drops per pound of body weight is generally safe. Smaller doses might help maintain a healthy gut microbiome and even provide cognitive benefits due to positive effects on the gut-brain axis.

Higher Doses:

  • Negative Effects: When the dosage increases significantly (e.g., exceeding 8 drops per pound of body weight), it can lead to noticeable changes in the gut microbiome. High concentrations can cause an increase in certain bacterial groups, leading to an imbalance known as dysbiosis. This imbalance can result in negative health outcomes, such as memory impairment and other gut-related issues.

  • Antibacterial Properties: Methylene blue has antibacterial properties, which can disrupt the balance of the gut microbiome at higher doses, potentially leading to adverse effects.

Oral Use:

  1. Dosage: The dosage of Methylene Blue is typically determined by body weight, at approximately 1-2 drops per 10 pounds of body weight.

  2. Preparation: Add methylene blue to a glass of filtered or bottled water.

  3. Consumption: Take the solution in the morning or early afternoon. Avoid consuming it late in the day to prevent sleep disturbances.

  4. Precautions: Do not take methylene blue during pregnancy or breastfeeding, or if you are taking certain medications like antidepressants, cyclosporine, sirolimus, or tacrolimus.

 

General Safety Tips:

  • Less is better.
  • More is worse. 

  • Lower Doses: Minimal impact, potential cognitive benefits.

  • Higher Doses: Disruption of the microbial balance, potential negative health outcomes.

  • Consult a Healthcare Professional: Always consult a healthcare professional for personalized advice before using methylene blue.

  • Storage: Keep the product in its original packaging, protected from light and moisture, and at an appropriate temperature.

 

Technical Information

If you are taking any medication, please check for interactions here and consult with your medical caregivers for more information.

Contraindications

  • Methylene blue can cause fetal harm when administered to a pregnant woman. An association exists between the use of methylene blue in amniocentesis and atresia of the ileum and jejunum, ileal occlusions and other adverse effects in the neonate. Methylene blue is contraindicated in women who are or may become pregnant. If this drug is used during pregnancy, or if the patient becomes pregnant while taking this drug, the patient should be apprised of the potential hazard to the fetus.
  • Intraspinal injection is contraindicated.
  • Methylene blue is contraindicated in patients with a known hypersensitivity to the drug.

Warnings

  • Methylene Blue should not be given by subcutaneous or intrathecal injection.
  • Methylene blue is a potent monoamine oxidase inhibitor: Methylene blue has been demonstrated to be a potent monoamine oxidase inhibitor (MAOI) and may cause potentially fatal serotonin toxicity (serotonin syndrome) when combined with serotonin reputake inhibitors (SRIs). Serotonin toxicity is characterized by development of neuromuscular hyperactivity (tremor, clonus, myoclonus and hyperreflexia, and, in the advanced stage, pyramidal rigidity); autonomic hyperactivity (diaphoresis, fever, tachycardia, tachypnoea, and mydraisis); and altered mental status (agitation, excitement, and in the advanced stage, confusion). If methylene blue is judged to be indicated, SRIs must be ceased, prior to treatment/procedure/surgery.

Drug Interactions

  • Methylene blue may interact with any drug that acts as a serotonin reuptake inhibitor (SRI) including, amongst others, selective serotonin reuptake inhbitors (SSRIs), serotonin and norepinephrine reuptake inhibitors (SNRIs), tricyclic antidepressants (TCAs), norepinephrine-dopamine reuptake inhibitors (NDRIs), triptans and ergot alkaloids; such combinations may have the consequence of potentially fatal serotonin toxicity (serotonin syndrome). Methylene blue should not be co-administered with any drug that acts as an SRI.

Precautions